Journal article

Multiscale Heterogeneity of White Matter Morphometry in Psychiatric Disorders

A Segal, RE Smith, S Chopra, S Oldham, L Parkes, K Aquino, SM Kia, T Wolfers, B Franke, M Hoogman, CF Beckmann, LT Westlye, OA Andreassen, A Zalesky, BJ Harrison, CG Davey, C Soriano-Mas, N Cardoner, J Tiego, M Yücel Show all

Biological Psychiatry Cognitive Neuroscience and Neuroimaging | Published : 2025

Abstract

Background: Interindividual variability in the neurobiological and clinical characteristics of mental illnesses are often overlooked by classical group-mean case-control studies. Studies using normative modeling to infer person-specific deviations of gray matter volume have indicated that group means are not representative of most individuals. The extent to which this variability is present in white matter morphometry, which is integral to brain function, remains unclear. Methods: We applied warped Bayesian linear regression normative models to T1-weighted magnetic resonance imaging data and mapped interindividual variability in person-specific white matter volume (WMV) deviations in 1294 ca..

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